The BIP responsivity phantoms are products developed in the framework of the well known BIP protocol.
Test and validate your system performance with our BIP Responsivity Phantom. Designed to be the cornerstone of assessing your detection system’s efficiency, this phantom is engineered to provide a decisive measure of responsivity, including scenarios with low light levels.
For diffuse optics instruments, responsivity quantifies the system’s ability to detect light emerging from tissues, a critical feature to assess system performance as required by the BIP protocol.
Why choose the BIP responsivity phantoms
- Lambertian Light Source: The BIP Responsivity Phantoms function as diffuse transmittance devices, offering light with Lambertian features, essential for accurate
responsivity assessments.
- Protocol Compliances: Our phantoms perfectly aligns with BIP protocol requirements. They come with a custom case featuring customizable aperture on both
sides, meeting the standards essential for reliable testing.
- Datasheet Precision: Each phantom is accompanied by a detailed datasheet, providing essential information such as attenuation in dB and the diffuse transmittance
factor κ
p(λ) for selected wavelengths ranging from 660 nm to 950 nm.
- Optimal Design: With a diameter of 10 cm and a thickness of 2 cm, our phantom is meticulously crafted to avoid boundary problems, to ensure ideal diffusion,
guaranteeing accurate responsivity assessments.
APPLICATIONS
Medical Device Development: Validate and optimize the efficiency and performances of different optical medical devices, ensuring accurate measurements and enhancing diagnostic capabilities in fields like oncology, neurology, and dermatology.
Multicenter Clinical Research: Elevate the precision of clinical studies by ensuring consistent, comparable and reliable performance. Use BIP Responsivity Phantoms to validate instruments, ensuring data accuracy and comparability in clinical trials.
Neuroimaging Studies: Enhance neuroimaging research by validating optical instruments utilized in observing brain activities. Validate instruments used for studying cognitive, sensory, and motor responses, providing reliable data for neuroscience breakthroughs.
Biomedical Engineering: Drive advancements in biomedical engineering by employing BIP Responsivity Phantoms and the BIP Protocol for accurate measurements. Validate and optimize instruments used in various biomedical applications, ensuring robust and reliable results.
Quality Control: Ensure the consistency and reliability of optical systems through stringent quality control. Implement the BIP Protocol to standardize instruments, enabling effective quality assurance processes in manufacturing and research environments.
Biophotonics Research: Facilitate groundbreaking research in biophotonics by employing BIP Responsivity Phantoms and the BIP Protocol. Ensure the accuracy of instruments used in diverse biophotonics studies, fostering innovation and scientific discovery.
Elevate your research, enhance your device development, and achieve unmatched reliability with our BIP Responsivity Phantoms. Unlock the potential of precision – explore our Responsivity Phantoms today!
WHAT IS THE BIP PROTOCOL
In the realm of noninvasive tissue probing using near-infrared light, advancements have propelled optical imaging techniques from laboratories to clinical applications, including breast cancer detection, neuroimaging, and diagnostic assessments of various tissues. However, the lack of standardized procedures and quality assessment tools has impeded the widespread adoption of these techniques. The challenge lies in deriving consistent physiological parameters from optical measurements, hindering comparisons between different systems or upgrades within the same system.
To address this gap, the BIP protocol (Basic Instrumental Performance) was developed, providing crucial guidelines for the comparison of diverse optical instruments. Focused on the fundamental properties of systems, independent of specific sample properties, BIP assesses critical factors such as detection efficiency, instrument response function (IRF), timing electronics and key parameters of the source component. By focusing on the essential characteristics, BIP ensures a reliable comparison between various optical systems, regardless of their complexity, measurement techniques, or clinical applications.
The BIP protocol’s comprehensive tests cover the source and detection components of instruments, evaluating parameters such as responsivity, differential nonlinearity (DNL), and temporal IRF. These tests are not only applicable to time-domain optical brain imagers but also extend to other photon-migration instruments based on TCSPC technology, including optical mammography systems and diffuse spectrometers. BIP’s versatility even allows adaptation for instruments measuring diffuse reflectance or transmittance of tissues.
While the BIP tests can stand alone, they seamlessly complement the application-oriented MEDPHOT and nEUROPt protocols. By ensuring consistency in the fundamental aspects of optical systems, the BIP protocol paves the way for improved data interpretation, robust research, and innovative developments across a spectrum of clinical and research applications.
Source: Heidrun Wabnitz, Dieter R. Taubert, Mikhail Mazurenka, Oliver Steinkellner, Alexander Jelzow, Rainer Macdonald, Daniel Milej, Piotr Sawosz, Michał Kacprzak, Adam Liebert, Robert Cooper, Jeremy Hebden, Antonio Pifferi, Andrea Farina, Ilaria Bargigia, Davide Contini, Matteo Caffini, Lucia Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Alessandro Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8) 086010 (14 August 2014) https://doi.org/10.1117/1.JBO.19.8.086010
The science behind responsivity
The BIP responsivity phantom plays a key role in assessing the responsivity of the detection system. The use of this phantom, together with a dedicated set up, allows for the determination of system efficiency in detecting light outcoming from tissues, which is a decisive feature in common cases of low light levels. For time-domain instruments, the responsivity of the detection system can be defined as the ratio between the photon count rate and the quantity of light emerging from the tissue in correspondence of the detector. Under the hypothesis of diffusive propagation and other conditions generally fullfilled for photon migration in biological tissue (like multiple isotropic scattering events), it is possible to consider the outcoming tissue surface as a Lambertian light source. In this case, the responsivity of the detection system can be evaluated taking into account the photon radiance of such source and the socalled diffuse transmittance factor κ p(λ).
At this point, it is clear that the phantom is crucial in providing adequate diffusion for incoming light. Indeed, our solid slab BIP phantom acts a diffuse transmittance device, to provide a light source with Lambertian features. It has a cylindrical shape with diameter of 10 cm and thickness of 2 cm. It comes with its case that has apertures on both sides, as required by the protocol.
